{"id":1638,"date":"2023-12-07T20:10:14","date_gmt":"2023-12-07T20:10:14","guid":{"rendered":"https:\/\/chemeng.iisc.ac.in\/symposium\/?page_id=1638"},"modified":"2025-01-17T16:47:56","modified_gmt":"2025-01-17T16:47:56","slug":"bharadwaj-vemparala","status":"publish","type":"page","link":"https:\/\/chemeng.iisc.ac.in\/symposium\/bharadwaj-vemparala\/","title":{"rendered":"Bharadwaj Vemparala"},"content":{"rendered":"<p><strong><span style=\"font-size: 18pt;\">Virus suppressive capacity of the early CD8 T cell response is predictive of natural control of SIV infection<\/span><\/strong><\/p>\n<p>Efforts to design therapies that elicit long-term remission of HIV are motivated by studies on natural controllers, a small set of individuals who spontaneously control the infection. Although a superior CD8 T cell response has been implicated in natural control, the underlying mechanisms are yet to be determined. In this study, we developed a mathematical model of virus dynamics that explicitly accounted for CD8 T cell dynamics and their cytotoxic effect on infected cells. We applied it to analyze virus dynamics in 16 SIV-infected macaques and elucidate the role of CD8 T cells in natural control. The model, for the first time, enabled simultaneous analysis of the canonical in vivo measurements like viremia and plasma SIV DNA together with a longitudinal quantitative marker of CD8 T cell responses, namely their viral suppressive capacity obtained by ex vivo measurements. Our model fit the data well and estimated that the recruitment rate and\/or maximal killing rate of CD8 T cells was up to 2-fold higher in controllers than non-controllers (p=0.013). Importantly, the cumulative suppressive capacity of CD8 T-cells over the first 4-6 weeks of infection was associated with set-point viremia (Spearman\u2019s rho=-0.51; p=0.05). Thus, our analysis identified the early cumulative suppressive capacity of CD8 T cells as a predictor of natural control. Furthermore, our model quantified the minimum capacity of this early CD8 T cell response necessary for long-term control. Our study presents new, quantitative insights into the role of CD8 T cells in the natural control of HIV infection. This framework can be extended to evaluating the role of CD8 T cell responses in post-treatment control.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Virus suppressive capacity of the early CD8 T cell response is predictive of natural control of SIV infection Efforts to design therapies that elicit long-term remission of HIV are motivated by studies on natural controllers, a small set of individuals who spontaneously control the infection. Although a superior CD8 T cell response has been implicated in natural control, the underlying [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/chemeng.iisc.ac.in\/symposium\/wp-json\/wp\/v2\/pages\/1638"}],"collection":[{"href":"https:\/\/chemeng.iisc.ac.in\/symposium\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/chemeng.iisc.ac.in\/symposium\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/chemeng.iisc.ac.in\/symposium\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chemeng.iisc.ac.in\/symposium\/wp-json\/wp\/v2\/comments?post=1638"}],"version-history":[{"count":3,"href":"https:\/\/chemeng.iisc.ac.in\/symposium\/wp-json\/wp\/v2\/pages\/1638\/revisions"}],"predecessor-version":[{"id":1903,"href":"https:\/\/chemeng.iisc.ac.in\/symposium\/wp-json\/wp\/v2\/pages\/1638\/revisions\/1903"}],"wp:attachment":[{"href":"https:\/\/chemeng.iisc.ac.in\/symposium\/wp-json\/wp\/v2\/media?parent=1638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}