Research

The incorporation of small alkyl groups, particularly methyl groups, into drug molecules has gained significant attention in the pharmaceutical industry for enhancing potency. Methylated drug molecules show increased selectivity and improved binding to specific targets, a phenomenon known as the “magic methyl effect.” In our research group, we investigate the mechanisms behind this enhancement and develop innovative methods for creating new therapeutic agents through methylation. We utilize advanced theoretical techniques like Molecular Dynamics (MD) and Monte Carlo (MC) simulations to model drug behavior at the molecular level. Additionally, we conduct experimental studies using Fluorescence Correlation Spectroscopy (FCS) and Small-Angle X-ray Scattering (SAXS) to analyze molecular interactions and structural characteristics. Through this comprehensive approach, we aim to significantly advance the development of effective new pharmaceuticals.

Non-recycled plastic mainly consists of polyolefins, which account for about 60% of global plastic waste. Sourced largely from the packaging industry, these materials typically end up polluting marine environments and harming marine life. Comprehensive recycling is essential, as traditional methods like pyrolysis and mechanical recycling are ineffective. In my research group, we are developing a processing technique to enhance the biodegradability of these thermoplastics while minimizing energy use. The main challenges are the high crystallinity and low wettability of polyolefins, which impede biodegradation. Our novel synthesis method addresses these issues and increases the potential for biodegradation by bacterial polymerase enzymes.